Combogesic® tablets are a combo of:
Acetaminophen
Ibuprofen
Non-opioid
pain relief
Giving you the relief
you need. Fast.
Combogesic® is a unique prescription combination of acetaminophen and ibuprofen in a single tablet.
Acetaminophen
Ibuprofen
QikSolv™ is a patented breakthrough formulation developed in the US for rapid dissolution.3
78%
More effective
pain relief than acetaminophen
alone (P<0.001)2
36%
More effective
pain relief than ibuprofen
alone (P<0.001)2
*Self-reported pain intensity scores were recorded over a 48-hour double blind treatment period using a 100mm visual analogue scale. The primary efficacy end point was the time-adjusted sum of pain intensity differences from baseline over a 48-hour period (SPID48).
Safety
Combogesic® is non-opioid.
Non-addictive.
Just relief.
Combogesic® tablets minimized the need for opioid analgesia by delaying the time to first request, reducing the overall consumption, and limiting the number of patients who required opioid rescue medication.2
Why Combogesic®?
It delivers superior relief
for mild to moderate
pain compared with
acetaminophen or
ibuprofen alone.
More effective
Significantly more effective pain relief than either acetaminophen or ibuprofen alone.2
Works faster
Faster onset of meaningful pain relief than acetaminophen or ibuprofen alone.2
Non-addictive forming
Reduced need for opioid rescue medication.2
FAQs for Combogesic® tablets
Combogesic® tablets contain a fixed-dose combination of 325 mg acetaminophen and 97.5 mg ibuprofen per tablet. These two active ingredients work via distinct yet complementary mechanisms to provide more effective pain relief than each individual active alone.2
Combogesic® offers a valuable option for the short-term management of mild to moderate acute pain in adults, with several key benefits. These include enhanced analgesic efficacy due to a synergistic action, simplified dosing through the combination of two agents in a single formulation, a well-established safety profile, and the potential to reduce reliance on opioids compared to monotherapy.
Combogesic® tablets are approved for adults only (18 years and above). The dosing regimen is 3 tablets every 6 hours as needed for pain relief, up to a maximum of 12 tablets per day.
Combogesic® tablets should be taken at the lowest effective dosage for the shortest duration, consistent with individual patient treatment goals, and should not be administered with other acetaminophen or NSAID-containing products.
Combogesic® tablets are contraindicated in:
- Patients with known hypersensitivity to acetaminophen, ibuprofen, other NSAIDs, or to any of the excipients in this product.
- Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients.
- The setting of coronary artery bypass graft (CABG) surgery
Warning / Precaution is advised in those patients with:
- Hypertension
- Heart Failure and Edema
- Renal Toxicity
- Anaphylactic Reactions
- Exacerbation of Asthma Related to Aspirin Sensitivity
- Serious Skin Reactions
- Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)
- Fetal Toxicity
- Hematologic Toxicity
To find the full list of warning and contraindications please see full Prescribing Information including the boxed warning.
Combogesic® is supported by a robust body of clinical data demonstrating its favorable safety profile. The postoperative safety profile of Combogesic® is comparable to that of acetaminophen and ibuprofen when used individually. By combining two active ingredients, Combogesic® enables the use of a lower dose of the NSAID component, thereby reducing the risk of adverse events typically associated with higher NSAID dosages or the use of more potent NSAIDs.
Overall, Combogesic® is well tolerated and demonstrates a strong safety profile when administered as both single and multiple doses.
Combogesic® tablets are intended for adults who need short-term relief of mild to moderate acute pain. They combine acetaminophen and ibuprofen, two active ingredients that work in different ways, providing more effective pain relief than either medicine alone.2
Healthcare professionals may recommend Combogesic® for:
- Common acute pain conditions.
- Situations where a non-opioid option is preferred to reduce risks of dependence or certain adverse effects.
- Patients who benefit from a multimodal approach, taking advantage of both medications together for consistent and reliable pain control.
The dosing allows patients to manage pain effectively while staying within dosing limits for acetaminophen and ibuprofen. Its patented formulation is designed for consistent, dependable relief, offering an advantage over taking the two medicines separately.