Resources
Clinical Studies
Effective.
Fast.
Multiple studies
prove it.
Efficacy and Safety
Clinical Study
Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial (Merry et al., 2010)
Clinically proven in an acute pain study of post-operative relief after removal of 1-4 wisdom teeth.
At maximum dosage, Combogesic® delivers at least 32% more effective pain relief than a full daily OTC dose of acetaminophen or ibuprofen alone.
Efficacy and Safety
Clinical Study
Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed‑dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double‑blind, Parallel‑group, Placebo‑controlled Trial (Daniels et al., 2018)
For patients undergoing extraction of 2-4 wisdom teeth, the fixed-dose acetaminophen + ibuprofen combination provided:
- Significantly more effective pain relief than either acetaminophen or ibuprofen alone.
- A faster onset of meaningful pain relief than acetaminophen or ibuprofen alone.
- Reduction in the percentage of patients receiving opioids and their consumption of opioid rescue medication.
Pooled Safety Data
An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic®/Combogesic®) in adults (Aitken et al., 2019)
This study pooled safety data for Combogesic® across four separate clinical trials showing that the incidence of adverse events experienced were similar to or below either acetaminophen, ibuprofen or placebo groups.
Overall, Combogesic® is well tolerated and has a strong safety profile at single and multiple doses.
Educational Materials
Tools to support your clinical decision making
Prescribing Information
Download the Prescribing Information for Combogesic® tablets